Romosozumab Tops Denosumab in Treating GIOP

TOPLINE:

Romosozumab (Evenity) is superior to denosumab (Prolia) in growing bone mineral density (BMD) in sufferers with glucocorticoid-induced osteoporosis (GIOP).

METHODOLOGY:

• Romosozumab is a US Meals and Drug Administration-approved humanized monoclonal antibody used to deal with osteoporosis in postmenopausal girls with a excessive danger for facture.

• The research included 70 adults with GIOP with a high-risk for osteoporotic fracture who acquired a ≥5 mg/day prednisolone dose for no less than 12 months previous to the research.

• Sufferers had been randomly assigned to obtain romosozumab subcutaneously (210 mg) each month for 12 doses or denosumab subcutaneously (60 mg) each 6 months for 2 doses.

• The first endpoint was the distinction in BMD on the lumber backbone from baseline to 1 12 months.

TAKEAWAY:

• Sufferers within the romosozumab group had a considerably better enhance in backbone BMD (+7.3%) after 12 months, in contrast with these within the denosumab group (+2.3%).

• Each teams had an analogous enhance in hip BMD at 1 12 months, whereas femoral neck BMD didn’t considerably enhance in both group in the course of the research interval.

• The romosozumab group had a decrease drop in serum C-terminal telopeptide of kind I collagen (CTX) however confirmed a rise in procollagen kind 1 N propeptide (P1NP), in contrast with the denosumab group.

• Sufferers within the romosozumab extra regularly reported injection web site ache, erythema, and swelling.

IN PRACTICE:

“Romosozumab could provide a brand new therapy choice in GIOP in high-risk sufferers,” write the authors.

STUDY DETAILS:

Chi-Chiu Mok, MD, Tuen Mun Hospital, Hong Kong, led the analysis and offered abstract OP0246 on June 2 on the European Alliance of Associations for Rheumatology (EULAR) 2023 Annual Assembly.

LIMITATIONS:

The trial’s small pattern measurement may restrict the interpretation of the outcomes.

DISCLOSURES:

The research was funded by a small grant from the Well being and Medical Analysis Fund of the Well being Bureau of the Authorities of Hong Kong.

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